EPS is associated with D2 occupancy of which percentage?

EPS is associated with D2 occupancy of which percentage?

• A. 60%+
• B. 50-75%
• C. 78%
• D. 90%

Answer: (C)

Dopamine D2 receptor blockade in motor pathways drives extrapyramidal symptoms, and the risk climbs as occupancy increases. The level at which EPS become notably likely is about three-quarters of receptors occupied—roughly 78%. Below this, you can get therapeutic effects with fewer EPS; well above it, EPS risk rises further. So 78% is the best descriptor of the occupancy linked to EPS. The other percentages either fall below the threshold where EPS become prominent or describe occupancy levels not as specifically tied to the EPS risk threshold.

Dopamine D2 receptor blockade in motor pathways drives extrapyramidal symptoms, and the risk climbs as occupancy increases. The level at which EPS become notably likely is about three-quarters of receptors occupied—roughly 78%. Below this, you can get therapeutic effects with fewer EPS; well above it, EPS risk rises further. So 78% is the best descriptor of the occupancy linked to EPS. The other percentages either fall below the threshold where EPS become prominent or describe occupancy levels not as specifically tied to the EPS risk threshold.