EPS is associated with D2 occupancy of which percentage?

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Multiple Choice

EPS is associated with D2 occupancy of which percentage?

Explanation:
Extrapyramidal symptoms arise when dopamine D2 receptor blockade in the striatum becomes very high. PET and clinical data show a clear threshold: around 78% occupancy of D2 receptors is when EPS risk begins to rise markedly, while effective antipsychotic effects can occur at somewhat lower occupancy. So the key point is that EPS is associated with roughly 78% D2 receptor occupancy.

Extrapyramidal symptoms arise when dopamine D2 receptor blockade in the striatum becomes very high. PET and clinical data show a clear threshold: around 78% occupancy of D2 receptors is when EPS risk begins to rise markedly, while effective antipsychotic effects can occur at somewhat lower occupancy. So the key point is that EPS is associated with roughly 78% D2 receptor occupancy.

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