Limited data on pregnancy effects includes possible cardiovascular defects in the first trimester and small left colon syndrome. Which of the following is true about these effects?

Limited data on pregnancy effects includes possible cardiovascular defects in the first trimester and small left colon syndrome. Which of the following is true about these effects?

• A. Small left colon syndrome
• B. Increased intraocular pressure
• C. Possible cardiovascular defects in the first trimester
• D. No data

Answer: (A)

In pregnancy safety data for antiretrovirals, only a few adverse effects have been reported, so some findings come from limited data. Small left colon syndrome is one such neonatal condition that has been described in infants exposed in utero to protease inhibitors. It presents as a functional narrowing of the left colon, leading to obstruction signs after birth, and has been reported in case series and reports related to maternal protease inhibitor exposure. Because this association has actually appeared in the literature, it’s considered a true, albeit limited, finding. In contrast, increased intraocular pressure isn’t a recognized, documented pregnancy safety signal for antiretrovirals, and saying there is no data ignores the reported cases of small left colon syndrome. So the statement that small left colon syndrome has been observed in this context best reflects the available information.

In pregnancy safety data for antiretrovirals, only a few adverse effects have been reported, so some findings come from limited data. Small left colon syndrome is one such neonatal condition that has been described in infants exposed in utero to protease inhibitors. It presents as a functional narrowing of the left colon, leading to obstruction signs after birth, and has been reported in case series and reports related to maternal protease inhibitor exposure. Because this association has actually appeared in the literature, it’s considered a true, albeit limited, finding.

In contrast, increased intraocular pressure isn’t a recognized, documented pregnancy safety signal for antiretrovirals, and saying there is no data ignores the reported cases of small left colon syndrome. So the statement that small left colon syndrome has been observed in this context best reflects the available information.